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TARGET SUMMARY home > target summary      

MPSBC has designated 141 targets, all of which are yeast membrane proteins.  These targets include the 44 proteins from baker’s yeast, Saccharomyces cerevisiae, listed in Table 1. The other 97 targets are orthologs (found in 11 other yeast species) for 14 of the S. cerevisiae target proteins.

 

Table 2 shows the current statuses for the orthologs that have been selected.

Table 3 gives an overall status summary for the 141 targets in the MPSBC pipeline

Click here to see database links for the target proteins.

Table 1.  MPSBC targets from Saccharomyces cerevisiae.

   
>
Target ID
Description
Status
UniProtKB
MPSBC-Alg3p
Dolichol-P-Man-dependent alpha(1-3)-mannosyltransferase
Expressed
P38179
MPSBC-Alg7p
UDP-N-acetyl-glucosamine-1-P transferase
Cloned
P07286
MPSBC-Are1p
Acyl-CoA:sterol acyltransferase
Purified
P25628
MPSBC-Arr3p
Arsenite transporter
Expressed
Q06598
MPSBC-Aur1p
IPC synthase
MP solubilized
P36107
MPSBC-Bor1p
Boron transporter 1
Crystallized
P53838
MPSBC-Chs1p
Chitin synthase I
Expressed
P08004
MPSBC-Chs2p
Chitin synthase II
Expressed
P14180
MPSBC-Chs3p
Chitin synthase III
Selected
P29465
MPSBC-Erg3p
C-5 sterol desaturase
MP solubilized
P32353
MPSBC-Erg25p
C-4 methyl sterol oxidase
MP solubilized
P53045
MPSBC-Ers1p
Cystine transporter
Cloned
P17261
MPSBC-Fks1p
Catalytic subunit of 1,3-beta-D-glucan synthase
Selected
P38631
MPSBC-Fmp30p
N-acylPE-specific phospholipase D
MP solubilized
Q02883
MPSBC-Gsc2p
Catalytic subunit of 1,3-beta-D-glucan synthase
Selected
P40989
MPSBC-Hxt13p
Hexose transporter
Work stopped
P39924
MPSBC-Kei1p
IPC synthase regulatory subunit
Expressed
Q06346
MPSBC-Ole1p
Delta(9) fatty acid desaturase
MP solubilized
P21147
MPSBC-Pfa3p
Palmitoyltransferase for Vac8p
Crystallized
P39924
MPSBC-Pfa4p
Palmitoyltransferase
MP solubilized
Q12006
MPSBC-Pfa5p
Palmitoyltransferase
MP solubilized
Q03289
MPSBC-Ptr2p
Oligopeptide transporter
Work stopped
P32901
MPSBC-Rce1p
CAAX prenyl protease
MP solubilized
Q03530
MPSBC-Rgt2p
Glucose sensor
Expressed
Q12300
MPSBC-Scs7p
Sphingolipid alpha-hydroxylase
Crystallized
Q03529
MPSBC-Snf3p
Glucose sensor
Expressed
P10870
MPSBC-Ssu1p
Sulfite efflux pump
MP solubilized
P41930
MPSBC-Ste2p
Pheromone alpha factor receptor
Purified
D6VTK4
MPSBC-Ste14p
Isoprenylcysteine carboxyl methyltransferase (ICMT)
Expressed
P32584
MPSBC-Ste24p
CAAX prenyl protease 1
Crystallized
P47154
MPSBC-Stv1p
V-type proton ATPase subunit a,
Golgi isoform
Expressed
P37296
MPSBC-Sur2p
Sphinganine C4-hydroxylase
Purified
P38992
MPSBC-Tok1p
Outward-rectifier K channel
MP solubilized
P40310
MPSBC-Trk1p
High-affinity K transport protein
Cloned
P12685
MPSBC-Trk2p
Low-affinity K transport protein
Cloned
P28584
MPSBC-Vhc1p
Vacuolar membrane cation-chloride cotransporter
MP solubilized
P38329
MPSBC-Vma3p
V-type proton ATPase subunit c
Expressed
P25515
MPSBC-Vma6p
V-type proton ATPase subunit d
Expressed
P32366
MPSBC-Vma11p
V-type proton ATPase subunit c'
Cloned
P32842
MPSBC-Vma12p
Vacuolar ATPase assembly integral membrane protein
MP solubilized
P32341
MPSBC-Vma16p
V-type proton ATPase subunit c''
Expressed
P23968
MPSBC-Vma22p
Vacuolar ATPase assembly protein
Expressed
P38784
MPSBC-Vph1p
V-type proton ATPase subunit a, vacuolar isoform
Expressed
P32563
MPSBC-Yvc1p
Vacuolar cation channel
Work stopped
Q12324
 
Table 2.  Current statuses for MPSBC targets that are orthologs from other yeast species.
Species  (Target ID suffix)
Aur1p
Bor1p
Ers1p
Fmp30p
Saccharomyces cerevisiae
MP solubilized
Crystallized
Cloned
MP solubilized
Saccharomyces bayanus  (Sb)
Selected
Crystallized
Expressed
Selected
Saccharomyces castellii  (Sca)
Selected
Crystallized
Expressed
Selected
Saccharomyces kluveri (Sklu)
Selected
Crystallized
Expressed
Selected
Saccharomyces kudriavzevii (Sku)
Selected
Crystallized
 
Selected
Saccharomyces mikatae (Sm)
Expressed
EM images
Expressed
Selected
Saccharomyces paradoxus (Sp)
Selected
Purified
Selected
Selected
Candida albicans  (Ca)
       
Candida glabrata (Cg)
Selected
Expressed
Selected
Chaetomium thermophilum (Ct)
 
Purified
   
Kluyveromyces lactis (Kl)
Selected
MP solubilized
Selected
Pichia pastoris (Pp)
Selected
 
Selected
 
Species  (Target ID suffix)
Ole1p
Pfa3p
Pfa4p
Rce1p
Saccharomyces cerevisiae
MP solubilized
Purified
MP solubilized
MP solubilized
Saccharomyces bayanus  (Sb)
Cloned
Selected
Saccharomyces castellii  (Sca)
MP solubilized
Expressed
Saccharomyces kluveri (Sklu)
Cloned
Selected
Saccharomyces kudriavzevii (Sku)
Cloned
Expressed
 
Expressed
Saccharomyces mikatae (Sm)
Cloned
MP solubilized
Expressed
Expressed
Saccharomyces paradoxus (Sp)
Cloned
Candida albicans  (Ca)
     
Candida glabrata (Cg)
Crystallized
Selected
Expressed
Expressed
Chaetomium thermophilum (Ct)
 
   
Kluyveromyces lactis (Kl)
Selected
Selected
Expressed
Expressed
Pichia pastoris (Pp)
Cloned
Selected
 
Species  (Target ID suffix)
Scs7p
Ste14p
Ste24p
Sur2p
Saccharomyces cerevisiae
Crystallized
MP solubilized
Crystallized
Purified
Saccharomyces bayanus  (Sb)
Purified
MP solubilized
Selected
Saccharomyces castellii  (Sca)
MP solubilized
MP solubilized
Selected
Saccharomyces kluveri (Sklu)
Selected
MP solubilized
Saccharomyces kudriavzevii (Sku)
Purified
MP solubilized
Purified
Saccharomyces mikatae (Sm)
Crystallized
MP solubilized
In PDB
Selected
Saccharomyces paradoxus (Sp)
Crystallized
MP solubilized
Selected
Candida albicans  (Ca)
Cloned
     
Candida glabrata (Cg)
Purified
MP solubilized
Selected
Chaetomium thermophilum (Ct)
 
   
Kluyveromyces lactis (Kl)
Purified
MP solubilized
Selected
Pichia pastoris (Pp)
Purified
MP solubilized
 
Purified
Species  (Target ID suffix)
Tok1p
Yvc1p
Saccharomyces cerevisiae
MP solubilized
Work stopped
Saccharomyces bayanus  (Sb)
Expressed
Saccharomyces castellii  (Sca)
Expressed
Work stopped
Saccharomyces kluveri (Sklu)
Work stopped
Saccharomyces kudriavzevii (Sku)
Expressed
Saccharomyces mikatae (Sm)
Expressed
Work stopped
Saccharomyces paradoxus (Sp)
Work stopped
Candida albicans  (Ca)
 
Candida glabrata (Cg)
Expressed
Work stopped
Chaetomium thermophilum (Ct)
 
Kluyveromyces lactis (Kl)
Expressed
Work stopped
Pichia pastoris (Pp)
Work stopped
 
Table 3. Overall MPSBC target status summary.
Status
Number of Targets
Status
Number of Targets
Selected
34
Crystallized
11
Cloned
12
EM images
1
Expressed
35
In PDB
1
MP solubilized
25
Work stopped
10
Purified
12
   
To download MPSBC's current Target Track xml file, go to http://sbkb.org/tt/downloads.html
and click on MPSBC.xml.gz
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